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About the symptoms of diabetic nephropathy

Read |Information source:SJZ kidney disease hospital|Published:2016-02-13


In early diabetes kidney disease, the patients show no symptoms. A small amount of albumin is the first sign of kidney damage in diabetes, but it only can be detected with urine test. With the renal function deterioration, the following clinical symptoms will become present.

Foamy urine

As diabetes kidney disease progresses, the filtering system will be impaired further. More proteins pass through glomeruli and end up in urine. Excess loss of protein in urine can cause foamy urine.


Edema is often noticed in the feet and legs firstly. With the disease progression, it will spread to throughout the body. It is due to leakage of protein in urine and also retention of fluid can contribute to it.

High blood pressure

High blood pressure can result from diabetes kidney disease. In return, it is an important accelerator of renal function decline. It is due to retention of fluids and sodium in body.

Weight loss

The patients with diabetes kidney disease may suffer weight loss and malnutrition. If the patients have protein in urine, they will have to limit the intake of proteins. Meanwhile, nausea, vomiting, and poor appetite can affect the intake of nutrients. All in all, the patients may suffer weight loss and malnutrition.

High cholesterol levels

Leakage of protein in urine can cause high cholesterol levels in blood. This can then increase the risk of cardiovascular disease and blood vessel diseases.


Fatigue can be seen in some cases of diabetes kidney disease. Anemia is the major culprit. Healthy kidneys can produce a hormone which can stimulate the bone marrow to produce red blood cells. However, the diseased kidneys will perform the function adequately, thus resulting in anemia.

Poor appetite

Poor appetite is mainly due to high levels of uremic toxins in body. Healthy kidneys can filter out urea nitrogen from body. However, once the kidneys are damaged, high levels of urea nitrogen will build up in body. The urea nitrogen will be decomposed into ammonia in gastrointestinal tract, thus leading to gastrointestinal problems like poor appetite, nausea and vomiting.

Article URL:http://www.sjzkidney.com/disease/dn/1027.html



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